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Biochemistry and Molecular Biology Education, Vol. 29 (4) (2001) pp. 142-143
© 2001 IUBMB. Published by Elsevier Science Ltd. All rights reserved.
PII: S1470-8175(01)00049-2

Article

Metabolic pathways: does the actual Gibbs free-energy change affect the flux rate?

J.Carlos Aledo caledo@uma.es

Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain

Abstract

Energy dissipation fulfils an important function in metabolism driving the flux of matter through metabolic pathways. The flux rate is a multivariable function. One of such variables affecting the flux is the actual free energy change. A particular case of metabolic pathway is analysed to illustrate this fact, using only general enzymic and thermodynamic concepts.

Keywords: Energy dissipation; Irreversible thermodynamics; Control flux

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