Volume 1. Structure and Dynamics of Membranes

Chapter 9. Material transport across permeability barriers by means of lipid vesicles

G. Cevc
Medizinische Biophysik, Technische Universität München, Klinikum r.d.I.,
Ismaningerstr. 22, D-1675 München, E.U. Germany

1. Introduction

2. Lipid bilayers and vesicles

2.1. Mixed lipid bilayers
2.2. Elasto-mechanic bilayer properties
3. Ultra flexible lipid vesicles as material carriers

4. Vesicle penetration through the artificial permeability barriers

4.1. Pressure driven transbarrier flow of lipid vesicles
4.2. Osmotically driven transbarrier flow of lipid vesicles
5. Vesicle penetration through the natural permeability barriers
5.1. Skin as a permeability barrier
5.2. Gradients and material flow across the intact skin
5.3. Spontaneous vesicle transport across the living skin
5.4. Kinetics of transdermal vesicle transport invivo
6. Therapeutic efficacy of the dermally applied lipid vesicles

7. Conclusions

References